Lyme arthritis: A small piece of the larger autoimmunity puzzle – Healio
Supply/Disclosures
Revealed by:
Supply:
Arvikar et al. Arth Rheum. 2017;doi:10.1002/artwork.39866.
Lantos PM, et al. Arth Rheum. 2020;doi:10.1002/artwork.41562.
Lochhead RB, et al. Nature Rev Rheum. 2021;doi:10.1038/s41584-021-00648-5.
Matzkin E, et al. J Am Acad Orthop Surg. 2015;doi: 10.5435/JAAOS-D-14-00388.
Schoen RE. Curr Opin Rheumatol. 2020;doi:10.1097/BOR.0000000000000698.
Stee…….
Supply/Disclosures
Revealed by:
Supply:
Arvikar et al. Arth Rheum. 2017;doi:10.1002/artwork.39866.
Lantos PM, et al. Arth Rheum. 2020;doi:10.1002/artwork.41562.
Lochhead RB, et al. Nature Rev Rheum. 2021;doi:10.1038/s41584-021-00648-5.
Matzkin E, et al. J Am Acad Orthop Surg. 2015;doi: 10.5435/JAAOS-D-14-00388.
Schoen RE. Curr Opin Rheumatol. 2020;doi:10.1097/BOR.0000000000000698.
Steere A, et al. J Clin Make investments. 2020;doi:10.1172/JCI138062.
Steere AC, et al. Ann Intern Med. 1987;doi: 10.7326/0003-4819-107-5-725.
Disclosures:
Arvikar, Calabrese, Kalish and Strle report no related monetary disclosures. Steere reviews consulting relationships with Roche Diagnostics, ViraMed and Zeus Diagnostics.
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Recognizing and managing early Lyme illness Might be straightforward: Simply Search for the bullseye. However when the rash goes away and the an infection reprimarys undeal withed for A professionaltracted interval, Lyme artworkhritis can develop. That is when The exact challenges startwork.
To be truthful, even Lyme artworkhritis Might be simply recognizable, Based mostly on Robert Kalish, MD, rheumatologist and director of rheumatology education at Tufts Medical Center. “Lyme artworkhritis Is usually going to be a swollen knee in round 90% of affected individuals,” he informed Healio Rheumatology.
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“Clinically, the knee or knees have An monumental effusion even after joint aspiration,” Cassandra Calabrese, DO, of the departworkment of rheumatologic and immunologic illness On the Cleveland Clinic, added.
Calabrese famous thOn The Reprimaryder of circumstances can manifest as persistent or intime periodittent ache and swelling in completely different huger joints, Similar to a Outcome of the shoulders, ankles or elbows. “It could go on for yrs, usually being extra persistent than intime periodittent,” she said.
In some circumstances, affected individuals are misrecognized with Lyme artworkhritis, when, Truly, They’ve ancompletely different Sort of artworkhritis alcollectively. “Furtherextra It is important To acintypeation that some affected individuals develop systemic autoimmune Sorts of artworkhritis, collectively with rheumatoid artworkhritis, spondyloartworkhropathies or psoriatic artworkhritis, following quickly after remedy for Lyme illness, Principally after early an infection,” Allen C. Steere, MD, principal investigator On The middle for Immunology & Inflammatory Illnesses at Massachusetts Widespread Hospital, said in an interview. “This will be confused with Lyme artworkhritis, However the remedy Ought to be approfessionalpriate DMARD remedy.”
An important current knowledge set from Lochhead and colleagues in Nature Critiques Rheumatology tackleed this confusion between Lyme artworkhritis and completely different artworkhritic circumstances. They wrote that Lyme artworkhritis is “characterised by extreme portions of interferon (IFN)-gamma and insufficient portions …….
